Force Spectroscopy: References
Summary of reported unbinding force of ligand-receptor bonds
| Streptavidin-biotin |
120-300
5-170
200 |
100-5000
0.05-60,000
N/A |
Yuan et al., 2000
Merkel et al., 1999
Wong et al., 1998 |
| Avidin-biotin |
115-170
5-170 |
100-5000 |
Yuan et al., 2000
Merkel et al., 1999 |
| W120F a-biotin |
90-170 |
0.05-60,000 |
Yuan et al., 2000 |
| Integrin aLb2-ICAM-1b |
20-320 |
100-5000 |
Zhang et al., 2002 |
| Integrin a5b1-fibronectin |
40-170 |
50-50,000 |
Li et al., 2003 |
| GTPase Rap-impbc |
40-160 |
300-80,000 |
Nevo et al., 2003 |
| SNARE d complex |
200-280 |
200-80,000 |
Yersin et al., 2003 |
| Plant lectin-asialofetuin |
37-65 |
100-30,000 |
Dettmann et al., 2000 |
| Selectin- sialyl Lewis X |
20-220 |
100-100,000 |
Zhang et al., 2004 |
| P-selectin-PSGL-1 e |
115-165 |
N/Af |
Fritz et al., 1998 |
| VE-cadherin-FC pair |
35-55 |
N/Af |
Baumgartner et al., 2000 |
| Cell adhesion proteoglycans |
40 +/- 15 |
N/A |
Dammer et al., 1995 |
| Meromyosin-actin |
15-25 |
N/A |
Nakajima et al., 1997 |
| Ferritin-antibody |
49 |
N/A |
Allen et al., 1997 |
| Human serum albumin-anitbody |
244 |
N/A |
Hinterdorfer et al., 1996 |
a W120F: a streptavidin mutant in which tryptophan 120 was replaced by a phenylalanine.
b ICAM-1: intercellular adhesion molecule-1.
c imp B : nuclear import receptor importin B1.
d PSGL-1: P-selectin Glycoprotein ligand-1
e SNARE: soluble N-ethyl-maleimide-sensitive factor attachment protein receptor.
f : Authors studied unbinding force vs. different pulling velocities, we were unable to convert the velocity to loading rates.
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